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Chemical Structure : GNE-7915 tosylate
CAS No.: 2070015-00-6
Catalog No.: PC-45425Not For Human Use, Lab Use Only.
GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 25 mg | $278 | In stock | |
| 100 mg | $728 | In stock | |
| 500 mg | Get quote |
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GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species.
Parkinson's Disease
Preclinical
| M.Wt | 615.597 | |
| Formula | C26H29F4N5O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-, 4-methylbenzenesulfonate (1:1) |
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1. Estrada AA, et al. J Med Chem. 2012 Nov 26;55(22):9416-33.
2. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15.
3. Kavanagh ME, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6.
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