PFE-360 (PF-06685360, PF360) is a potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM.
PFE-360 induces a morphological kidney phenotype resembling that of the LRRK2 ko rats, whereas no effects in the lung.
PFE-360 treatment induces morphological changes characterised by darkened kidneys and progressive accumulation of hyaline droplets in the renal proximal tubular epithelium, the estimated PFE-360 unbound plasma concentration off 10-fold the IC50 (30 nM) to achieve full peripheral LRRK2 inhibition.
