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Chemical Structure : PFE-360
CAS No.: 1527475-61-1
Catalog No.: PC-62508Not For Human Use, Lab Use Only.
PFE-360 (PF-06685360) is a potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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PFE-360 (PF-06685360, PF360) is a potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM.
PFE-360 induces a morphological kidney phenotype resembling that of the LRRK2 ko rats, whereas no effects in the lung.
PFE-360 treatment induces morphological changes characterised by darkened kidneys and progressive accumulation of hyaline droplets in the renal proximal tubular epithelium, the estimated PFE-360 unbound plasma concentration off 10-fold the IC50 (30 nM) to achieve full peripheral LRRK2 inhibition.
| M.Wt | 308.345 | |
| Formula | C16H16N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-methyl-4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrrole-2-carbonitrile |
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1. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15.
2. Andersen MA, et al. Toxicology. 2018 Feb 15;395:15-22.
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