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SR 9444

Chemical Structure : SR 9444

CAS No.: 1442659-77-9

SR 9444 (SR9444)

Catalog No.: PC-62372Not For Human Use, Lab Use Only.

SR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively; shows reasonable selectivity against a panel of 116 kinases; exhibits good cell potency, inhibits LRRK2:G2019S-induced mitochondrial dysfunction in SHSY5Y cells.

Physicochemical Properties

M.Wt 696.849
Formula C39H48N6O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-((2-((6-(4-(1H-indazol-3-yl)benzamido)hexyl)amino)-2-oxoethyl)(isobutyl)amino)-2-oxoethyl)-6-methoxychromane-3-carboxamide

References

1. Feng Y, et al. ACS Chem Biol. 2013 Aug 16;8(8):1747-54.

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