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Chemical Structure : LRRK2-IN-1
CAS No.: 1234480-84-2
Catalog No.: PC-42726Not For Human Use, Lab Use Only.
A potent LRRK2 inhibitor with IC50s of 13 nM/6 nM for wild-type/G2019S mutant LRRK2 repectively (0.1 mM ATP in the assay).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $352 | In stock | |
| 100 mg | $600 | In stock |
Bulk size, bulk discount!
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A potent LRRK2 inhibitor with IC50s of 13 nM/6 nM for wild-type/G2019S mutant LRRK2 repectively (0.1 mM ATP in the assay); shows modest activity against LRRK2 A2016T (IC50=2.45 uM) and LRRK2 A2016T+G2019S mutant (IC50=3.08 uM); also inhibits DCLK1 (IC50=2.61 nM) and 2 (IC50=45 nM); induces dephosphorylation of Ser910 and Ser935 of LRRK2 and alters the cytoplasmic localisation of LRRK2.
| M.Wt | 570.6852 | |
| Formula | C31H38N8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl- |
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1. Deng X, et al. Nat Chem Biol. 2011 Apr;7(4):203-5.
2. Weygant N, et al. Mol Cancer. 2014 May 6;13:103.
3. Luerman GC, et al. J Neurochem. 2014 Feb;128(4):561-76.
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