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Chemical Structure : JH-II-127
CAS No.: 1700693-08-8
Catalog No.: PC-45094Not For Human Use, Lab Use Only.
A potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $176 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | $880 | In stock |
Bulk size, bulk discount!
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A potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively; also inhibits LRRK2 A2016T with IC50 of 47.7 nM; substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at 0.1-0.3 uM in a variety of cell types; inhibits Ser935 phosphorylation in mouse brain; orally active.
Parkinson's Disease
Preclinical
| M.Wt | 416.8615 | |
| Formula | C19H21ClN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl- |
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1. Hatcher JM, et al. ACS Med Chem Lett. 2015 Apr 7;6(5):584-9.
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