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G2019S-LRRK2 inhibitor 38

Chemical Structure : G2019S-LRRK2 inhibitor 38

CAS No.: 2704564-03-2

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G2019S-LRRK2 inhibitor 38

Catalog No.: PC-72161Not For Human Use, Lab Use Only.

G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).
    G2019S-LRRK2 inhibitor 38 selectively inhibit phosphorylation of Ser935 in vitro, and in brain, lung, kidney and spleen in G2019S-LRRK2 mice.

    Physicochemical Properties

    M.Wt 379.467
    Formula C24H21N5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R)-1-[[3-(2-methyl-4-pyridyl)-1H-indazol-5-yl]amino]tetralin-6-carbonitrile

    References

    1. Robert K Leśniak, et al. Eur J Med Chem. 2022 Feb 5;229:114080.

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