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RCGD 423

Chemical Structure : RCGD 423

CAS No.: 108237-91-8

RCGD 423 (RCGD423)

Catalog No.: PC-63195Not For Human Use, Lab Use Only.

RCGD 423 (RCGD423) is a small molecule gp130 modulator that prevents articular cartilage degeneration and promotes repair both in vitro and in vivo.

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Biological Activity

RCGD 423 (RCGD423) is a small molecule gp130 modulator that prevents articular cartilage degeneration and promotes repair both in vitro and in vivo.
RCGD 423 increases proliferation while reducing apoptosis and hypertrophic responses in adult chondrocytes in vitro, elicits different signalling in chondrocytes than IL-6 family cytokines and can inhibit their catabolic effects.
RCGD 423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation in rat partial meniscectomy model, improves cartilage healing in rat full-thickness osteochondral defect model.

Physicochemical Properties

M.Wt 331.231
Formula C15H11BrN2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-bromophenyl)-4-phenylthiazol-2-amine

References

1. Shkhyan R, et al. Ann Rheum Dis. 2018 Feb 7. pii: annrheumdis-2017-212037.

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