| Cat. No. |
Product Name |
Information |
| PC-72481 |
Nico-52
IL-4 inhibitor
|
Nico-52 (IL-4 inhibitor 52) is a specific small-molecule Interleukin-4 (IL-4) inhibitor with EC50 of 1.81 uM and SPR KD of 1.8 uM, disrupts type II IL-4 signaling in cells. |
| PC-35897 |
LMT-28
IL-6 inhibitor
|
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130. |
| PC-63195 |
RCGD423
gp130 modulator
|
RCGD423 (RCGD-423) is a small molecule gp130 modulator that prevents articular cartilage degeneration and promotes repair both in vitro and in vivo. |
| PC-62479 |
SP4206
IL-2α receptor inhibitor
|
SP4206 is a high-affinity (Kd=70 nM) small molecule that blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2. |
| PC-45128 |
Suplatast tosilate
Th2 cytokine inhibitor
|
Suplatast tosilate (IPD-1151T) is a Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. |
| PC-45769 |
YM-90709
IL-5 receptor inhibitor
|
YM-90709 (YM90709) is a potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively. |
| PC-26288 |
KYH1943
IL-33 antagonist
|
KYH1943 is a specific small-molecule inhibitor targeting IL-33/ST2 signaling, suppresses IL-33-induced Treg activation and proliferation. |
| PC-26287 |
KYH1942
IL-33 antagonist
|
KYH1942 is a specific small-molecule inhibitor targeting IL-33/ST2 signaling, suppresses IL-33-induced Treg activation and proliferation. |
| PC-26254 |
AIK3a305
IL-1β inhibitor
|
AIK3a305 (AIK3-305) is an allosteric inhibitor of Jmitogen-activated protein kinases (MAPK), particularly JNK, and a potent and selective, orally available inhibitor IL-1β release in human monocyte-derived macrophages with IC50 of 28 nM. |
| PC-26149 |
IRA10L
IL-36R inhibitor
|
IRA10L is a specific small molecule inhibitor of IL-36 receptor (IL-36R), inhibits IL-36-induced hCXCL1 secretion in HT29 cells with IC50 of 4.72 µM for IL-36γ, 5.81 µM for IL-36α, 14.55 µM for IL-36β, and 6.49 µM for the IL-36α/β/γ cocktail. |
| PC-25755 |
JNJ627
IL-17A inhibitor
|
JNJ627 (JNJ-627) is a small-molecule allosteric inhibitor of the IL-17A homodimer, inhibits IL-17A binding to IL-17RA with IC50 of 16 nM in TR-FRET assays. |
| PC-25547 |
4L2-P13D
IL-11 antagonist
|
4L2-P13D is a potent, high-affinity macrocyclic peptide antagonist of interleukin-11 (IL-11) with binding KD of 11 nM and IC50 of 2.8 uM, shows significant renoprotective effects and antirenal fibrosis both in vitro and in vivo. |
