Catalog No.: PC-72481Not For Human Use, Lab Use Only.
Nico-52 (IL-4 inhibitor 52) is a specific small-molecule Interleukin-4 (IL-4) inhibitor with EC50 of 1.81 uM and SPR KD of 1.8 uM, disrupts type II IL-4 signaling in cells.
Nico-52 (IL-4 inhibitor 52) is a specific small-molecule Interleukin-4 (IL-4) inhibitor with EC50 of 1.81 uM and SPR KD of 1.8 uM, disrupts type II IL-4 signaling in cells.
Nico-52 exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 μM but oes not affect the levels of STAT-6 in in THP-1 cells in response to IL-4.
Nico-52 inhibits IL-13 activity with an EC50 of 18.2 μM, indicating that the molecule is about 10-fold more potent for inhibiting IL-4 than IL-13.
