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Chemical Structure : LMT-28
CAS No.: 1239600-18-0
Catalog No.: PC-35897Not For Human Use, Lab Use Only.
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6-induced luciferase activity), selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130.
LMT-28 does not affect LIF-induced STAT3 activation and not inhibit IL-11 stimulation on HepG2 cells.
LMT-28 binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex.
LMT-28 inhibits IL-6–induced proliferation of the human erythroleukemic cell line TF-1 with IC50 of 7.5 uM.
LMT-28 inhibits IL-6–induced TNF-α production, ameliorates the progression of pancreatitis in mice.
| M.Wt | 311.422 | |
| Formula | C17H29NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-((2S,3S)-3-hydroxy-2-methyl-4-methylenenonanoyl)-4-isopropyloxazolidin-2-one |
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1. Hong SS, et al. J Immunol. 2015 Jul 1;195(1):237-45.
2. Armstead WM, et al. Transl Stroke Res. 2018 Feb 23. doi: 10.1007/s12975-018-0617-z.
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