Catalog No.: PC-35897Not For Human Use, Lab Use Only.
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130.
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6-induced luciferase activity), selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130.
LMT-28 does not affect LIF-induced STAT3 activation and not inhibit IL-11 stimulation on HepG2 cells.
LMT-28 binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex.
LMT-28 inhibits IL-6–induced proliferation of the human erythroleukemic cell line TF-1 with IC50 of 7.5 uM.
LMT-28 inhibits IL-6–induced TNF-α production, ameliorates the progression of pancreatitis in mice.
