| Cat. No. |
Product Name |
Information |
| PC-49391 |
Rytvela
IL-1RI inhibitor
|
Rytvela (Peptide 101.10, d-(RYTVELA)) is a potent, selective, allosteric negative modulator (antagonist) of IL-1 receptor I (IL-1RI), inhibits dose-dependently IL-1-induced PGE2 formation (IC50= 0.5 nM) and IL-1-induced human thymocyte (TF-1 cell) proliferation (IC50=2 nM). |
| PC-72919 |
A-552
L-36γ antagonist
|
A-552 (A552) is a potent, small molecule antagonist of human IL-36γ, exhibits Ki of 31/54 nM in IL-36γ evoked CXCL1 release in human/mouse cellular assays. |
| PC-72481 |
IL4 inhibitor 52
IL4 inhibitor
|
IL4 inhibitor 52 is the first IL-4 small-molecule inhibitor (EC50=1.81 uM) with potency for the cytokine and disrupts type II IL-4 signaling in cells. |
| PC-35897 |
LMT-28
IL-6 inhibitor
|
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130. |
| PC-62479 |
SP4206
IL-2α receptor inhibitor
|
SP4206 is a high-affinity (Kd=70 nM) small molecule that blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2. |
| PC-45128 |
Suplatast tosilate
Th2 cytokine inhibitor
|
Suplatast tosilate (IPD-1151T) is a Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. |
| PC-45769 |
YM-90709
IL-5 receptor inhibitor
|
YM-90709 (YM90709) is a potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively. |
| PC-23454 |
IRI-1
IL-1R1/IL-1β inhibitor
|
IRI-1 is a specific interleukin-1 receptor I (IL-1R1)/interleukin 1β (IL-1β) interaction inhibitor with IC50 of 5.15 uM. |
| PC-22797 |
JNJ-77242113
IL-23 receptor inhibitor
|
JNJ-77242113 is a highly potent, selective, oral peptide inhibitor of IL-23 receptor with Kd of 7.1 pM, potently and selectively inhibits proximal IL-23 signaling (IC50=5.6 pM) without impacting IL-12 signaling. |
| PC-21192 |
hIL-1β antagonist Compound (S)-2
hIL-1β antagonist
|
Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM. |
| PC-20616 |
Bindarit
MCP-1 inhibitor
|
Bindarit (AF2838) is a selective inhibition of inflammatory chemokine MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, shows immunosuppressive effects anti-inflammatory activity. |
