JNJ627 | IL-17A inhibitor | Probechem Biochemicals

Chemical Structure : JNJ627

JNJ627 (JNJ-627)

Catalog No.: PC-25755Not For Human Use, Lab Use Only.

JNJ627 (JNJ-627) is a small-molecule allosteric inhibitor of the IL-17A homodimer, inhibits IL-17A binding to IL-17RA with IC50 of 16 nM in TR-FRET assays.

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Biological Activity

JNJ627 (JNJ-627) is a small-molecule allosteric inhibitor of the IL-17A homodimer, inhibits IL-17A binding to IL-17RA with IC50 of 16 nM in TR-FRET assays.

Physicochemical Properties

M.Wt	522.71
Formula	C29H38N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(3-(((S)-1-cyclohexyl-2-oxo-2-(phenylamino)ethyl)carbamoyl)benzyl)-2,2-dimethylthiomorpholine-3-carboxamide

References

1. Milla ME, et al. ACS Med Chem Lett. 2025 Oct 6;16(11):2301-2308.

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JNJ627 (JNJ-627)

Biological Activity

Physicochemical Properties

References

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