Chemical Structure : AIK3a305
CAS No.:
2419902-92-2
AIK3a305
(AIK3-305)
Catalog No.: PC-26254Not For Human Use, Lab Use Only.
AIK3a305 (AIK3-305) is an allosteric inhibitor of Jmitogen-activated protein kinases (MAPK), particularly JNK, and a potent and selective, orally available inhibitor IL-1β release in human monocyte-derived macrophages with IC50 of 28 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AIK3a305 (AIK3-305) is an allosteric inhibitor of Jmitogen-activated protein kinases (MAPK), particularly JNK, and a potent and selective, orally available inhibitor IL-1β release in human monocyte-derived macrophages with IC50 of 28 nM.
AIK3a305 does not interfere expression levels of IL-1α, IL-2, IL-6, IL-8 or GM-CSF.
AIK3a305 shows direct biophysical interactions to p38α MAPK with SPR KD of 12 nM.
AIK3a305 (10-20 mg/kg) inhibits IL-1β secretion in LPS endotoxic shock model in male BALB/c mice.
AIK3a305 selectively inhibited LPS- and palmitate-induced IL1β expression in macrophages, while protecting hepatocytes from intracellular lipid accumulation and lipoapoptosis.
AIK3a305 attenuated disease progression in animals fed either a HFD or a CDAA diet, as evidenced by improved liver histopathology, including reduced steatosis and inflammation, in preclinical models of MASLD.
Physicochemical Properties
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M.Wt
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532.05
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Formula
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C26H30ClN3O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-(4-(4-chlorophenoxy)piperidin-1-yl)-5-(4-ethoxyphenoxy)-N,N-dimethylpyridine-3-sulfonamide
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References
1. Berlana Á, et al. Biomed Pharmacother. 2026 Feb;195:119052.
2. Zegarra-Valdivia JA, et al. Geroscience. 2022 Aug;44(4):2243-2257.
3. Carrasco E, et al. Eur J Med Chem. 2021 Nov 5;223:113620.
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