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Chemical Structure : LY3509754
CAS No.: 2452464-73-0
Catalog No.: PC-21800Not For Human Use, Lab Use Only.
LY3509754 is a potent, selective and oral small molecule inhibitor of IL-17A with high binding potency(KD=2.14 nM), dose-dependently prevents human IL-17A and IL-17AF from binding human IL-17RA.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $358 | In stock | |
| 5 mg | $558 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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LY3509754 is a potent, selective and oral small molecule inhibitor of IL-17A with high binding potency(KD=2.14 nM), dose-dependently prevents human IL-17A and IL-17AF from binding human IL-17RA.
LY3509754 displays no inhibition of IL-17C, IL-17E, or IL-17F interacting with their cognate receptors. LY3509754 dose-dependently inhibits IL-17A-induced CXCL1/GROα (IL-8 for canine) in primary or cell lines from species of interest (in human keratinocytes, IC50=8.25 nM; plasma protein binding-adjusted geomean, IC50=3.67 nM).
LY3509754 shows potential effect for treatment of psoriasis and other immune-mediated diseases.
| M.Wt | 586.52 | |
| Formula | C24H27F5N8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((S)-(4,4-difluorocyclohexyl)(7-((S)-2-methoxy-1-((S)-2-oxo-4-(trifluoromethyl)imidazolidin-1-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)methyl)-4-methyl-1,2,5-oxadiazole-3-carboxamide |
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