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Chemical Structure : Bindarit
CAS No.: 130641-38-2
Catalog No.: PC-20616Not For Human Use, Lab Use Only.
Bindarit (AF2838) is a selective inhibition of inflammatory chemokine MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, shows immunosuppressive effects anti-inflammatory activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | $758 | In stock | |
| 1 g | Get quote |
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Bindarit (AF2838) is a selective inhibition of inflammatory chemokine MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, shows immunosuppressive effects anti-inflammatory activity.
Bindarit displays no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23, RANTES/CCL5, and IL8/CXCL8.
Bindarit dose-dependently inhibits MCP-1 and TNF-alpha production induced in vitro in monocytes by LPS and Candida albicans, does not affect the production of the cytokines IL-1, IL-6, or the chemokines IL-8, MIP-1alpha and RANTES.
Bindarit reduces monocyte recruitment and local MCP-1 production, induced by carrageenan or IL-1 injection.
Bindarit protects mice against trinitrobenzene sulfonic acid-induced colitis.
Bindarit reduces tumor growth and macrophage recruitment, rendering necrotic tumor masses in melanoma-bearing mice.
| M.Wt | 324.38 | |
| Formula | C19H20N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-[(1-benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid |
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1. Gazzaniga S, et al. J Invest Dermatol. 2007 Aug;127(8):2031-41.
2. Grassia G, et al. Cardiovasc Res. 2009 Dec 1;84(3):485-93.
3. Bhatia M, et al. Inflamm Res. 2008 Oct;57(10):464-71.
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