IRI-1 | IL-1R1/IL-1β inhibitor | Probechem Biochemicals

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Chemical Structure : IRI-1

IRI-1 (IL-1R1/IL-1β interaction inhibitor)

Catalog No.: PC-23454Not For Human Use, Lab Use Only.

IRI-1 is a specific interleukin-1 receptor I (IL-1R1)/interleukin 1β (IL-1β) interaction inhibitor with IC50 of 5.15 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IRI-1 is a specific interleukin-1 receptor I (IL-1R1)/interleukin 1β (IL-1β) interaction inhibitor with IC50 of 5.15 uM.
IRI-1 inhibits the secretion of TNF-α and IL-6 in a dose- dependent pattern with IC50 of 8.0 and 15 μM, respectively in THP-1 and Saos-2 cell line.
IRI-1 also inhibits IL-1β-induced phosphorylation of key signalling proteins downstream of receptor (IL-1R1).
IRI-1 inhibits IL-1β-mediated phosphorylation of IL1-R1, JNK, IRAK-4, and ERK in THP-1 cells.

Physicochemical Properties

M.Wt	428.93
Formula	C22H21ClN2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-chloro-4-methoxyphenyl)-3-((1-(3,4-dimethylphenyl)-1-oxopropan-2-yl)thio)pyrazin-2(1H)-one

References

1. Pirzada RH, et al. Int J Biol Macromol. 2024 Nov 7;282(Pt 5):137295.

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IRI-1 (IL-1R1/IL-1β interaction inhibitor)

Biological Activity

Physicochemical Properties

References

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