Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : IRI-1
Catalog No.: PC-23454Not For Human Use, Lab Use Only.
IRI-1 is a specific interleukin-1 receptor I (IL-1R1)/interleukin 1β (IL-1β) interaction inhibitor with IC50 of 5.15 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
IRI-1 is a specific interleukin-1 receptor I (IL-1R1)/interleukin 1β (IL-1β) interaction inhibitor with IC50 of 5.15 uM.
IRI-1 inhibits the secretion of TNF-α and IL-6 in a dose- dependent pattern with IC50 of 8.0 and 15 μM, respectively in THP-1 and Saos-2 cell line.
IRI-1 also inhibits IL-1β-induced phosphorylation of key signalling proteins downstream of receptor (IL-1R1).
IRI-1 inhibits IL-1β-mediated phosphorylation of IL1-R1, JNK, IRAK-4, and ERK in THP-1 cells.
| M.Wt | 428.93 | |
| Formula | C22H21ClN2O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Pirzada RH, et al. Int J Biol Macromol. 2024 Nov 7;282(Pt 5):137295.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
