VH4011499 | HIV-1 capsid inhibitor | Probechem Biochemicals

Chemical Structure : VH4011499

VH4011499 (VH-499)

Catalog No.: PC-25440Not For Human Use, Lab Use Only.

VH4011499 (VH-499) is a highly potent HIV-1 capsid inhibitor with EC50 and EC90 of 0.023 nM and 0.061 nM respectively.

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Biological Activity

VH4011499 (VH-499) is a highly potent HIV-1 capsid inhibitor with EC50 and EC90 of 0.023 nM and 0.061 nM respectively.
VH4011499 (VH-499) exhibits antiviral activity against additional viral strains with E50 of 0.020-0.069 nM.
VH4011499 (VH-499) inhibits a broad spectrum of HIV-1 isolates, and chimeric viruses derived from sequences of multiple group M subtypes, including subtypes A, B, C, F, G, and CRF01_AE.
VH4011499 (VH-499) also blocks nuclear import, total reverse transcript production, integration, virion assembly, and maturation.

Physicochemical Properties

M.Wt	918.19
Formula	C37H29ClF9N9O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-4-oxo-7-(3,3,3-trifluoropropoxy)-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-3-(difluoromethyl)-5,5-difluoro-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

References

1. Wang C, et al. Antimicrob Agents Chemother. 2025 Sep 3:e0030925.

VH4011499 (VH-499)

Biological Activity

Physicochemical Properties

References

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