Bevirimat | HIV-1 maturation inhibitor

Chemical Structure : Bevirimat

CAS No.: 174022-42-5

Bevirimat (PA-457, MPC-4326, YK FH312)

Catalog No.: PC-22328Not For Human Use, Lab Use Only.

Bevirimat (PA-457) is a potent HIV inhibitor that inhibits HIV Gag protein processing and viral maturation.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
50 mg	$358	In stock
100 mg		Get quote

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Biological Activity

Bevirimat (PA-457) is a potent HIV inhibitor that inhibits HIV Gag protein processing and viral maturation.
Bevirimat (PA-457) potently inhibits replication of both WT and drug-resistant HIV-1 isolates.
Bevirimat (PA-457) demonstrate that the compound acts by disrupting a late step in Gag processing involving conversion of the capsid precursor (p25) to mature capsid protein (p24).
Bevirimat (PA-457) is a specific inhibitor of capsid precursor, CA-SP1.

Physicochemical Properties

M.Wt	584.84
Formula	C36H56O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-(3-carboxy-3-methylbutanoyl)oxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

References

1. Li F, et al. Virology. 2006 Dec 5-20;356(1-2):217-24.

2. Li F, et al. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13555-60.

Bevirimat (PA-457, MPC-4326, YK FH312)

Biological Activity

Physicochemical Properties

References

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