VH3739937 | HIV-1 maturation inhibitor

Chemical Structure : VH3739937

VH3739937 (VH-937)

Catalog No.: PC-23258Not For Human Use, Lab Use Only.

VH3739937 (GSK3739937, VH-937) is a potent, specific HIV-1 maturation inhibitor with EC50 of 1.8 nM against NLRepRlucP373S reporter virus.

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Biological Activity

VH3739937 (GSK3739937, VH-937) is a potent, specific HIV-1 maturation inhibitor with EC50 of 1.8 nM against NLRepRlucP373S reporter virus.
VH3739937 (GSK3739937, VH-937) potently inhibits all phenotyped HIV-1 strains with EC90 values ≤ 10.0 nM.
VH3739937 (GSK3739937, VH-937) exhibits potent antiviral activity against all HIV-1 laboratory strains, clinical isolates, and recombinant viruses examined, with half-maximal effective concentration (EC50) values ≤ 5.0 nM.
VH3739937 (GSK3739937, VH-937) inhibits viruses less susceptible to other HIV-1 maturation inhibitors, including A364V in single-cycle assays (EC50, 32.0 nM).

Physicochemical Properties

M.Wt	841.21
Formula	C50H72N4O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(((3-cyanopyridin-2-yl)oxy)methyl)-4-((1R,3aS,5aS,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a,13a-hexamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)cyclohex-3-ene-1-carboxylic acid

References

1. Brian McAuliffe, et al. Viruses. 2024 Sep 24;16(10):1508.

VH3739937 (VH-937)

Biological Activity

Physicochemical Properties

References

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