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Chemical Structure : Cabotegravir
CAS No.: 1051375-10-0
Catalog No.: PC-21806Not For Human Use, Lab Use Only.
Cabotegravir (GSK-1265744) is a potent, selective HIV-1 integrase inhibitor with IC50 of 3 nM in biochemical integrase strand transfer assay (INST).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $118 | In stock | |
| 50 mg | $178 | In stock | |
| 100 mg | $288 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Cabotegravir (GSK-1265744) is a potent, selective HIV-1 integrase inhibitor with IC50 of 3 nM in biochemical integrase strand transfer assay (INST).
Cabotegravir (GSK-1265744) shows IC50 of 1.3 nM in MT-4 cell assays, and a pHIV IC50 of <2 nM against the Q148K variant, IC50 of 0.2 nM in peripheral blood mononuclear cell (PBMC) HIV multiround replication assays.
Cabotegravir (GSK-1265744) formulated as a long-acting (LA) injectable protects macaques from intrarectal simian/human immunodeficiency virus.
| M.Wt | 405.36 | |
| Formula | C19H17F2N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S,11aR)-N-(2,4-Difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide |
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1. Johns BA, et al. J Med Chem. 2013 Jul 25;56(14):5901-16.
2. Andrews CD, et al. Science. 2014 Mar 7;343(6175):1151-4.
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