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JB-161

Chemical Structure : JB-161

CAS No.: 2517345-93-4

JB-161 (JB161)

Catalog No.: PC-27266Not For Human Use, Lab Use Only.

JB-161 is a small molecule inhibitor of histone demethylase KDM5B, inhibits JFCR39 human cancer cell line panel with GI50 values in low micromolar range, shows antitumour effects.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JB-161 is a small molecule inhibitor of histone demethylase KDM5B, inhibits JFCR39 human cancer cell line panel with GI50 values in low micromolar range, shows antitumour effects.

Physicochemical Properties

M.Wt 410.36
Formula C14H8F6N4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4H-Pyrazolo[3,4-d]pyrimidine-4-thione, 1,5-dihydro-3-methyl-6-(trifluoromethyl)-1-[3-[(trifluoromethyl)thio]phenyl]-

References

1. Hara T, et al. Cancer Med. 2026 Jun;15(6):e72058.

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