| Cat. No. |
Product Name |
Information |
| PC-24550 |
Bomedemstat ditosylate
LSD1 inhibitor
|
Bomedemstat ditosylate (IMG-7289) is a potent, selective, irreversible and orally active LSD1 (KDM1A) inhibitor, increases H3K4 and H3K9 methylation. |
| PC-23548 |
Rhein
FTO inhibitor
|
Rhein is a pan inhibitor of the ALKBH proteins, inhibits ALKBH2, ALKBH3 and FTO with IC50 values of 9.1 μM, 5.3 μM and 21.0 μM, respectively. |
| PC-22847 |
FTO inhibitor FB23
FTO inhibitor
|
FTO inhibitor FB23 is a potent and selective FTO demethylase inhibitor with IC50 of 60 nM, directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity. |
| PC-22358 |
TK-129
KDM5B inhibitor
|
TK-129 is a highly potent, selective, and orally efficacious KDM5B ((lysine demethylase 5B, JARID1B) inhibitor with IC50 of 44 nM in homogeneous time-resolved fluorescence assay (HTRF). |
| PC-22089 |
ALKBH5 inhibitor TD19
ALKBH5 inhibitor
|
ALKBH5 inhibitor TD19 is a specific, covalent inhibitor of RNA demethylase ALKBH5, inhibits ALKBH5-induced demethylation with IC50 of 1.5-3 uM. |
| PC-21987 |
PBIT
KDM5 inhibitor
|
PBIT is a specific small molecule inhibitor of JARID1 family of histone lysine demethylases (KDM5) with IC50 of 3 uM for JARID1B (KDM5B or PLU1), inhibits H3K4me3 demethylation in vitro and in vivo. |
| PC-21915 |
ALKBH1 inhibitor 13h
ALKBH1 inhibitor
|
ALKBH1 inhibit 13h is a potent, isoform selective, and cell-active DNA 6mA demethylase ALKBH1 inhibitor with 26 nM and 1.39 uM in FP and enzyme activity assay, respectively. |
| PC-21875 |
WS-384
LSD1 inhibitor
|
WS-384 is a specific, small-molecule inhibitor dually targeting LSD1 (IC50=338.8 nM) and the DCN1-UBC12 interaction (IC50=14.8 uM). |
| PC-21840 |
P3FI-90
KDM3B inhibitor
|
P3FI-90 is a specific small molecule inhibitor of KDM3B with SPR KD of 7.68 uM, inhibits PAX3-FOXO1 activity and blocks PAX3-FOXO1 downstream target gene expression. |
| PC-21684 |
iPHF8
PHF8 inhibitor
|
iPHF8 (inhibitor of PHF8) is a specific inhibitor of protein demethylase PHF8 with IC50 of 2.01 uM in Succinate-Glo JmjC demethylase assays, and SPR KD value of 240 nM. |
| PC-21211 |
GSK-J4
KDM6A/6B inhibitor
|
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively, GSK-J4 s a cell permeable prodrug of GSK-J1. |
| PC-21085 |
JMJD5 inhibitor 19j
JMJD5 inhibitor
|
JMJD5 inhibitor 19j is a potent selective small molecule inhibitor of 2OG-dependent oxygenase JMJD5 (KDM8), shows high selectivity over other human 2OG oxygenases. |
