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ALKBH5 inhibitor TD19

Chemical Structure : ALKBH5 inhibitor TD19

CAS No.:

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ALKBH5 inhibitor TD19

Catalog No.: PC-22089Not For Human Use, Lab Use Only.

ALKBH5 inhibitor TD19 is a specific, covalent inhibitor of RNA demethylase ALKBH5, inhibits ALKBH5-induced demethylation with IC50 of 1.5-3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ALKBH5 inhibitor TD19 is a specific, covalent inhibitor of RNA demethylase ALKBH5, inhibits ALKBH5-induced demethylation with IC50 of 1.5-3 uM.
    TD19 does not inhibit FTO and ALKBH3 at 100 uM. Displays Kd value of 145 nM in isothermal titration calorimetry (ITC) assay, and Kd of 17.5 nM in microscale thermophoresis (MST) assays.
    TD19 irreversibly modifies the residues C100 and C267, inhibits ALKBH5 binding to m6A-RNA substrate.
    TD19 displays good anticancer efficacy in acute myeloid leukemia and glioblastoma multiforme cell lines (MOLM13 cell IC50=9.5 uM, U87 cell IC50=7.2 uM).

    Physicochemical Properties

    M.Wt 248.30
    Formula C12H12N2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-benzyl-4-cyclopropyl-1,2,4-thiadiazolidine-3,5-dione

    References

    1. Lai GQ, et al. RSC Chem Biol. 2024 Feb 19;5(4):335-343.

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