Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TK-129
Catalog No.: PC-22358Not For Human Use, Lab Use Only.
TK-129 is a highly potent, selective, and orally efficacious KDM5B ((lysine demethylase 5B, JARID1B) inhibitor with IC50 of 44 nM in homogeneous time-resolved fluorescence assay (HTRF).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TK-129 is a highly potent, selective, and orally efficacious KDM5B ((lysine demethylase 5B, JARID1B) inhibitor with IC50 of 44 nM in homogeneous time-resolved fluorescence assay (HTRF).
TK-129 also potently inhibits KDM5A with an IC50 value of 0.079 μM but is less effective toward KDM5C (IC50 = 0.353 μM).
TK-129 increases the expression level of KDM5B substrate H3K4me3 protein in neonatal rat cardiac fibroblasts (NRCFs), with low cytotoxicity.
TK-129 alleviates Ang II-induced activation, migration, and proliferation of myocardial fibroblasts in NRCFs.
TK-129 alleviates myocardial remodeling induced by isoproterenol (ISO) in pathological myocardial remodeling in vivo.
| M.Wt | 305.38 | |
| Formula | C15H23N5O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kai Tang, et al. J Med Chem. 2022 Oct 13;65(19):12979-13000.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
