DDO-02267 | ALKBH5 inhibitor | Probechem Biochemicals

Chemical Structure : DDO-02267

DDO-02267 (DDO 02267)

Catalog No.: PC-23678Not For Human Use, Lab Use Only.

DDO-02267 is a potent, specific, lysine-targeting covalent inhibitor of ALKBH5 with binding KD of 2.8 uM in ITC assay and IC50 of 174.7 nM in FP assay, specifically targets lysine 132 (Lys132).

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Biological Activity

DDO-02267 is a potent, specific, lysine-targeting covalent inhibitor of ALKBH5 with binding KD of 2.8 uM in ITC assay and IC50 of 174.7 nM in FP assay, specifically targets lysine 132 (Lys132).
DDO-02267 demonstrates more than 20-fold selectivity over FTO and ALKBH3.
DDO-02267 (0-80 uM) increases the levels of cellular m6A and targets ALKBH5-AXL signaling axis in AML cells.

Physicochemical Properties

M.Wt	400.36
Formula	C18H12N2O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(((3-formyl-4-hydroxynaphthalen-1-yl)sulfonyl)carbamoyl)isonicotinic acid

References

1. Fei WL, et al. Eur J Med Chem. 2024 Dec 23;284:117183.

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DDO-02267 (DDO 02267)

Biological Activity

Physicochemical Properties

References

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