Chemical Structure : DC551040
CAS No.:
2133291-32-2
DC551040
(DC-551040)
Catalog No.: PC-26436Not For Human Use, Lab Use Only.
DC551040 is a potent, selective, irreversible and orally bioavailable LSD1 inhibitor with IC50 of 2.14 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DC551040 is a potent, selective, irreversible and orally bioavailable LSD1 inhibitor with IC50 of 2.14 nM.
DC551040 exhibits excellent selectivity on LSD1 over LSD2 and MAO.
DC551040 interacts covalently with LSD1, occupies the catalytic site of LSD1.
DC551040 displays significant potency in inhibiting antiproliferative activities in several AML cell lines, including MV-4-11 (IC50 = 79.51 nM), Kasumi-1 (IC50 = 25.77 nM), and HL60 (IC50 = 40.35 nM), while shows weak inhibitory activity against non-AML cell lines, with an IC50 value over 20 uM.
DC551040 shows inhibitory effects in AML patient-derived cells.
DC551040 exhibits a significant anticancer effect on cell differentiation in leukemic MV-4-11 cells, decreases level of H3K4me2 in MV-4-11 cells.
DC551040 (2 mg/kg, 10 mg/kg, oral) demonstrates antitumor effect in Kasumi-1 and MV-4-11 xenograft model.
Physicochemical Properties
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M.Wt
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389.52
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Formula
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C22H32FN3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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piperidin-4-ylmethyl 4-fluoro-4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidine-1-carboxylate
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References
1. Wang J, et al. Signal Transduct Target Ther. 2026 Mar 23;11(1):108.
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