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Chemical Structure : S2172
Catalog No.: PC-23355Not For Human Use, Lab Use Only.
S2172 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with Ki of 0.27 uM.
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S2172 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with Ki of 0.27 uM.
S2172 does not inhibit LSD2, monoamine oxidase A (MAO-A), and MAO-B, in an in vitro peroxidase assay.
S2172 inhibits cell growth effectively (GI50=8.2 μM) against differentiated glioma cell lines (LN229).
S2172 affects H3K4me2 modifications, affects super-enhancer-dependent regulation of gene expression in GSCs.
S2172 (10 mg/kg) eradicates tumor cells in GSC brain tumor mouse model.
| M.Wt | 372.46 | |
| Formula | C22H26F2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shinjo K, et al. Cancer Gene Ther. 2024 Nov 5. doi: 10.1038/s41417-024-00847-8.
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