Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Demethylase-S2172
S2172

Chemical Structure : S2172

CAS No.: 2262499-18-1

Add to Favorites

S2172

Catalog No.: PC-23355Not For Human Use, Lab Use Only.

S2172 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with Ki of 0.27 uM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

S2172 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with Ki of 0.27 uM.
S2172 does not inhibit LSD2, monoamine oxidase A (MAO-A), and MAO-B, in an in vitro peroxidase assay.
S2172 inhibits cell growth effectively (GI50=8.2 μM) against differentiated glioma cell lines (LN229).
S2172 affects H3K4me2 modifications, affects super-enhancer-dependent regulation of gene expression in GSCs.
S2172 (10 mg/kg) eradicates tumor cells in GSC brain tumor mouse model.

Physicochemical Properties

M.Wt 372.46
Formula C22H26F2N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

rel-N1-[(1R,2S)-2-[3,5-Difluoro-2-(phenylmethoxy)phenyl]cyclopropyl]-1,4-cyclohexanediamine

References

1. Shinjo K, et al. Cancer Gene Ther. 2024 Nov 5. doi: 10.1038/s41417-024-00847-8.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: