| Cat. No. |
Product Name |
Information |
| PC-27206 |
KDM2A inhibitor 183c
KDM2A inhibitor
|
KDM2A inhibitor 183c is a potent inhibitor of histone lysine-specific demethylase 2A (KDM2A, FBXL11 or JHDM1A) with high activity against KDM2A (IC50=11 nM), KDM2B (IC50=13 nM) and KDM7A (IC50=9.6 nM) in vitro. |
| PC-26949 |
NCGC00247743
KDM4 inhibitor
|
NCGC00247743 is a selective inhibitor of histone lysine demethylase KDM4/JMJD2s with IC50 of 10 nM for KDM4B, inhibits LNCaP cell growth with IC50 in the μM range, shows no or weak activity for KDM5A/JARID1A. |
| PC-26560 |
KDM5-C49 hydrochloride
KDM5 inhibitor
|
KDM5-C49 hydrochloride is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively. |
| PC-26540 |
GSK-LSD1
LSD1 inhibitor
|
GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1, KDM1) inhibitor with IC50 of 16 nM. |
| PC-26437 |
DC551040 dihydrochloride
LSD1 inhibitor
|
DC551040 dihydrochloride is a potent, selective, irreversible and orally bioavailable LSD1 inhibitor with IC50 of 2.14 nM. |
| PC-26423 |
TAS1440
LSD1 inhibitor
|
TAS1440 (TAS-1440) is a potent, selectve, histone H3-competitive non-covalent LSD1 inhibitor with IC50 of 4.8 nM, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways. |
| PC-25883 |
JMJD6 inhibitor 7p
JMJD6 inhibitor
|
JMJD6 inhibitor 7p is potent, selective JMJD6 inhibitor with IC50 of 681 nM, shows no activity against other JmjC domain-containing protein family members. |
| PC-25582 |
Methylstat
JHDMs inhibitor
|
Methylstat is a selective inhibitor of Jumonji C domain-containing histone demethylases (JHDMs) in cells, preferentially inhibits JMJD2A (H3K9me3 and H3K36me3 demethylase), JMJD2E (H3K9me3 demethylase) and JMJD3 (H3K27me3 demethylase). |
| PC-24718 |
Tranylcypromine hydrochloride
LSD1 inhibitor
|
Tranylcypromine (SKF385) hydrochloride is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) and monoamine oxidase (MAO), inhibits LSD1, MAO-A and MAO-B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. |
| PC-24469 |
FTO inhibitor F97
FTO inhibitor
|
F97 is a specific small molecule inhibitor of fat mass and obesity-associated protein (FTO) with IC50 of 0.45 uM, selectively inhibits m6A demethylation by FTO rather than ALKBH5, and has minimal effect on m1A demethylation by ALKBH3. |
| PC-24227 |
GSK690 hydrochloride
LSD1 inhibitor
|
GSK690 hydrochloride is a potent, reversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1, KDM1A) with IC50 of 37 nM, binding Kd value of 9 nM. |
| PC-24023 |
ALKBH5 inhibitor 18l
ALKBH5 inhibitor
|
ALKBH5 inhibitor 18l is a potent, selective, covalent inhibitor of N6-methyladenosine (m6A) demethylase ALKBH5 with Kd of 804 nM, IC50 of 0.62 uM. |
