Chemical Structure : ALKBH2 inhibitor AH2-14c
CAS No.:
ALKBH2 inhibitor AH2-14c
Catalog No.: PC-23547Not For Human Use, Lab Use Only.
ALKBH2 inhibitor AH2-14c is the ethyl ester, cell membrane permeable prodrug of AH2-15c, which is a potent and selective inhibitor of 2OG-dependent DNA demethylase AlkB homolog 2 (ALKBH2) with IC50 of 31 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ALKBH2 inhibitor AH2-14c is the ethyl ester, cell membrane permeable prodrug of AH2-15c, which is a potent and selective inhibitor of 2OG-dependent DNA demethylase AlkB homolog 2 (ALKBH2) with IC50 of 31 nM.
AH2-14c exhibits nti-proliferation and anti-migration abilities of AH2-14c on U87 cells.
AH2-14c induces apoptosis in GBM cell lines.
AH2-14c shows significantly increased anti-viability activity against U87 cells with an IC50 value of 4.56 uM, compare with AH2-15c.
AH2-14c directly binds to ALKBH2 and increases the levels of DNA 3meC in cells (5 uM).
Physicochemical Properties
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M.Wt
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406.49
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Formula
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C23H26N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Ethyl 1-(5-((2,2-dimethyl-1-phenylpropyl)carbamoyl)pyridin-2-yl)-1H-pyrazole-4-carboxylate
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References
1. Xu K, et al. Eur J Med Chem. 2024 Nov 14;282:117054.
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