YTH domain inhibitor N-7

Chemical Structure : YTH domain inhibitor N-7

Catalog No.: PC-22985Not For Human Use, Lab Use Only.

YTH domain inhibitor N-7 is a specific small molecule, pan-inhibitor of YTH domain-containing m6A RNA readers with IC50 of 30-48 uM for human YTHDF1, YTHDF2, YTHDF3, YTHDC1, and YTHDC2 proteins.

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Biological Activity

YTH domain inhibitor N-7 is a specific small molecule, pan-inhibitor of YTH domain-containing m6A RNA readers with IC50 of 30-48 uM for human YTHDF1, YTHDF2, YTHDF3, YTHDC1, and YTHDC2 proteins.
N-7 shows selective binding to YTH domain proteins over non-YTH m6A recognition protein FTO.

Physicochemical Properties

M.Wt	372.43
Formula	C18H24N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(9-(3,3-bis(hydroxymethyl)cyclobutyl)-9H-purin-6-yl)-2,7-diazaspiro[4.4]nonan-3-one

References

1. Wang CH, et al. RSC Chem Biol. 2024 Jul 25;5(9):914-923.

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