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Chemical Structure : NCL-1
Catalog No.: PC-23285Not For Human Use, Lab Use Only.
NCL-1 is a specific small molecule inhibitor of LSD1 (KDM1A) with IC50 of 2.5 uM.
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NCL-1 is a specific small molecule inhibitor of LSD1 (KDM1A) with IC50 of 2.5 uM.
NCL-1 promotes inhibitory epigenetic modifications, inhibits cell proliferation of PELP1-driven (MCF-7-PELP1) and HER2-driven (MCF-7-HER2) breast cancer cells with IC50 of 10-16.5 uM.
NCL-1 significantly reduced the proliferation of glioma cells, promotes up regulation of the p53 target genes p21 and PUMA.
NCL-1 mimicks the effects of siRNA-mediated KDM1A knockdown and effectively inhibits KDM1A activity in four neuroblastoma cell lines and a patient-representative cell model.
| M.Wt | 443.55 | |
| Formula | C27H29N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Valerie Cortez, et al. Breast Cancer Res. 2012 Jul 19;14(4):R108.
2. Ueda R, et al. J Am Chem Soc. 2009;14:17536–17537.
3. Sprüssel A, et al. J Clin Med. 2024 Oct 12;13(20):6081.
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