| Cat. No. |
Product Name |
Information |
| PC-35295 |
CBB3001
LSD1 inhibitor
|
CBB3001 (CBB-3001) is a novel potent, selective histone demethylase LSD1 inhibitor with IC50 of 21.25 uM. |
| PC-43206 |
ORY-1001
LSD1 inhibitor
|
ORY-1001 (RG-6016) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases. |
| PC-43163 |
ML324
KDM4 inhibitor
|
ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity). |
| PC-43122 |
SP2509
LSD1 inhibitor
|
SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase. |
| PC-42967 |
IOX1
2OG oxygenases inhibitor
|
IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7. |
| PC-62978 |
L-α-Hydroxyglutaric acid disodium
Dioxygenase inhibitor
|
L-α-Hydroxyglutaric acid disodium (L-2-Hydroxyglutarate, L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases. |
| PC-62871 |
Bizine
LSD1 inhibitor
|
Bizine is a phenelzine analog that inhibits LSD1 with Ki of 59 nM, displays 23-fold, 63-fold, and >100-fold selectivity for LSD-1 over MAOA, MAOB, and LSD2 respectively. |
| PC-62840 |
LSD1-IN-11p
LSD1 inhibitor
|
LSD1-IN-11p is a potent, reversible LSD1 inhibitor with IC50/Kd of 79/21 nM. |
| PC-62837 |
KDM4D-IN-10r
KDM4D inhibitor
|
KDM4D-IN-10r is a potent, selective histone lysine demethylase 4D (KDM4D) inhibitor with IC50 of 0.41 uM. |
| PC-62835 |
KDM5A-IN-50
KDM5 inhibitor
|
KDM5A-IN-50 is a potent, selective, and orally bioavailable pan KDM5 enzyme inhibitor with biochemical IC50 of 45/56/55 nM for KDM5A/KDM5B/KDM5C respectively. |
| PC-62327 |
AS8351
KDM5B inhibitor
|
AS8351 (NS 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409, inhibits lysine demethylase 5B (KDM5B). |
| PC-62294 |
KDM5-C49
KDM5 inhibitor
|
KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively. |
