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MINA53 inhibitor 10

Chemical Structure : MINA53 inhibitor 10

CAS No.: 2863676-85-9

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MINA53 inhibitor 10

Catalog No.: PC-72263Not For Human Use, Lab Use Only.

MINA53 inhibitor 10 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.5 uM, selective over NO66, KDM4-6 and other JmjC oxygenases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MINA53 inhibitor 10 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.5 uM, selective over NO66, KDM4-6 and other JmjC oxygenases.
    MINA53 inhibitor 10 display no significant inhibitory effect against 20G Oxygenase panel (IC50>30 uM).
    MINA53 inhibitor 10 binds to MINA53 by directly interacting with the iron cofactor.
    MINA53 inhibitor 10 demonstrated antiproliferative effect in a panel of leukemia and lymphoma cell lines (HL60 IC50=14 uM), also sensitized cancer cells to conventional chemotherapy.

    Physicochemical Properties

    M.Wt 290.337
    Formula C14H14N2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-oxo-2-((3-phenylpropyl)thio)-1,6-dihydropyrimidine-5-carboxylic acid

    References

    1. Radosław P Nowak, et al. J Med Chem. 2021 Dec 9;64(23):17031-17050.

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