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Chemical Structure : FB23-2
CAS No.: 2243736-45-8
Catalog No.: PC-36169Not For Human Use, Lab Use Only.
FB23-2 is a potent, selective inhibitor of the mRNA N 6-methyladenosine (m 6A) demethylase FTO, directly bind to FTO, inhibits FTO demethylation of m6 A in RNA in vitro with IC50 of 2.6 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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FB23-2 is a potent, selective inhibitor of the mRNA N 6-methyladenosine (m 6A) demethylase FTO, directly bind to FTO, inhibits FTO demethylation of m6 A in RNA in vitro with IC50 of 2.6 uM.
FB23-2 demonstrates significantly improved anti-proliferative activity on NB4 and MONOMAC6 cells with IC50 of 0.8-1.5 uM, compared with parental compound FB23.
FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells in vitro.
FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice.
| M.Wt | 392.236 | |
| Formula | C18H15Cl2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 60 mg/mL |
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| Chemical Name/SMILES |
2-((2,6-dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-N-hydroxybenzamide |
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1. Huang Y, et al. Cancer Cell. 2019 Apr 15;35(4):677-691.e10.
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