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Chemical Structure : T-448 free base
Catalog No.: PC-35903Not For Human Use, Lab Use Only.
T-448 free base (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts.
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T-448 free base (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts.
T-448 increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction.
T-448 shows unique therapeutic approaches for central nervous system disorders associated with epigenetic dysregulation.
| M.Wt | 328.434 | |
| Formula | C17H20N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matsuda S, et al. Neuropsychopharmacology. 2018 Dec 22. doi: 10.1038/s41386-018-0300-9.
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