FTO-02 | FTO inhibitor | Probechem Biochemicals

Chemical Structure : FTO-02

FTO-02 (FTO 02, FTO inhibitor FTO-02 )

Catalog No.: PC-72225Not For Human Use, Lab Use Only.

FTO-02 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 2.18 uM, 40-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=85.5 uM).

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Biological Activity

FTO-02 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 2.18 uM, 40-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=85.5 uM).

Physicochemical Properties

M.Wt	252.273
Formula	C15H12N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-methoxypyrimidin-5-yl)naphthalen-2-ol

References

1. Sarah Huff, et al. ACS Chem Biol. 2021 Feb 19;16(2):324-333.

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FTO-02 (FTO 02, FTO inhibitor FTO-02 )

Biological Activity

Physicochemical Properties

References

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