You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Demethylase-FTO-04
FTO-04

Chemical Structure : FTO-04

CAS No.: 2585198-87-2

FTO-04 (FTO inhibitor FTO-04)

Catalog No.: PC-72226Not For Human Use, Lab Use Only.

FTO-04 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 3.39 uM, 13-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=39.4 uM).

Packing Price Stock Quantity
5 mg $198 In stock
10 mg $298 In stock
25 mg $458 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FTO-04 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 3.39 uM, 13-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=39.4 uM).
FTO-04 prevented neurosphere formation in patient-derived glioblastoma stem cells (GSCs) without inhibiting the growth of healthy neural stem cell-derived neurospheres.
FTO-04 increased m6A and m6Am levels in GSCs consistent with FTO inhibition.

Physicochemical Properties

M.Wt 258.299
Formula C12H10N4OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO (2.59 mg/mL)

Chemical Name/SMILES

6-(2-methoxypyrimidin-5-yl)benzo[d]thiazol-2-amine

References

1. Sarah Huff, et al. ACS Chem Biol. 2021 Feb 19;16(2):324-333.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: