| Cat. No. |
Product Name |
Information |
| PC-42195 |
D-alpha-Hydroxyglutaric acid disodium
Dioxygenase inhibitor
|
D-alpha-Hydroxyglutaric acid disodium (D-2-HG, D-2-hydroxyglutarate) is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases. |
| PC-23678 |
DDO-02267
ALKBH5 inhibitor
|
DDO-02267 is a potent, specific, lysine-targeting covalent inhibitor of ALKBH5 with binding KD of 2.8 uM in ITC assay and IC50 of 174.7 nM in FP assay, specifically targets lysine 132 (Lys132). |
| PC-23677 |
ALKBH5 inhibitor Ena21
ALKBH5 inhibitor
|
Ena21 is a selective small molecule m6A demethylation enzyme ALKBH5 inhibitor with IC50 of 15.7 uM, shows little activity for FTO. |
| PC-23676 |
ALKBH5 inhibitor Ena15
ALKBH5 inhibitor
|
Ena15 is a selective small molecule m6A demethylation enzyme ALKBH5 inhibitor with IC50 of 18.3 uM, also enhances the demethylase activity of FTO. |
| PC-23648 |
ZLD115
FTO inhibitor
|
ZLD115 is a potent, selective inhibitor of fat mass and obesity-associated protein (FTO) with IC50 of 2.3 uM in PAGE-based assays. |
| PC-23548 |
Rhein
ALKBH inhibitor
|
Rhein is a pan inhibitor of the ALKBH proteins, inhibits ALKBH2, ALKBH3 and FTO with IC50 values of 9.1 μM, 5.3 μM and 21.0 μM, respectively. |
| PC-23547 |
ALKBH2 inhibitor AH2-14c
ALKBH2 inhibitor
|
ALKBH2 inhibitor AH2-14c is the ethyl ester, cell membrane permeable prodrug of AH2-15c, which is a potent and selective inhibitor of 2OG-dependent DNA demethylase AlkB homolog 2 (ALKBH2) with IC50 of 31 nM. |
| PC-23546 |
ALKBH2 inhibitor AH2-15c
ALKBH2 inhibitor
|
ALKBH2 inhibitor AH2-15c is a potent and selective inhibitor of 2OG-dependent DNA demethylase AlkB homolog 2 (ALKBH2) with IC50 of 31 nM in fluorescence polarization (FP) assays, >200-fold selectivity over other AlkB subfamily members. |
| PC-23356 |
S2157
LSD1 inhibitor
|
S2157 is a selective, brain-permeable inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with IC50 of 0.89 uM, >200-fold selective over LSD2, MAO-A and MAO-B. |
| PC-23355 |
S2172
LSD1 inhibitor
|
S2172 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with Ki of 0.27 uM. |
| PC-23354 |
S2116
LSD1 inhibitor
|
S2116 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) withIC50 of 0.74 uM. |
| PC-23285 |
NCL-1
LSD1 inhibitor
|
NCL-1 is a specific small molecule inhibitor of LSD1 (KDM1A) with IC50 of 2.5 uM. |
