| Cat. No. |
Product Name |
Information |
| PC-42149 |
KDM5-IN-48
KDM5 inhibitor
|
KDM5-IN-48 is a potent, selective and orally bioavailable KDM5 inhibitor with biochemical IC50 of 15.1, 4.7 and 65.5 nM for KDM5A, KDM5B and KDM5C, respectively. |
| PC-42195 |
D-alpha-Hydroxyglutaric acid disodium
Dioxygenase inhibitor
|
D-alpha-Hydroxyglutaric acid disodium (D-2-HG, D-2-hydroxyglutarate) is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases. |
| PC-24227 |
GSK690 hydrochloride
LSD1 inhibitor
|
GSK690 hydrochloride is a potent, reversible, mechanism based inhibitor of lysine specific demethylase 1 (LSD1, KDM1A) with IC50 of 37 nM, binding Kd value of 9 nM. |
| PC-24023 |
ALKBH5 inhibitor 18l
ALKBH5 inhibitor
|
ALKBH5 inhibitor 18l is a potent, selective, covalent inhibitor of N6-methyladenosine (m6A) demethylase ALKBH5 with Kd of 804 nM, IC50 of 0.62 uM. |
| PC-24003 |
JBI-097
LSD1/HDAC6 inhibitor
|
JBI-097 is a potent, dual LSD1/HDAC6 inhibitor with IC50 of 6/48 nM respectively, also inhibits HDAC8 (IC50=71 nM), does not inhibit other HDACs. |
| PC-24002 |
LH-1802
LSD1 inhibitor
|
LH1802 is a potent, selective and reversible inhibitor of lysine-specific demethylase 1 (LSD1) with EC50 of 470 nM (CD86). |
| PC-24001 |
CBB1007 trihydrochloride
LSD1 inhibitor
|
CBB1007 trihydrochloride is a cell-permeable, potent, reversible and substrate competitive (LSD1, KDM1A) selective inhibitor with IC50 of 5.27 uM. |
| PC-24000 |
CBB1007
LSD1 inhibitor
|
CBB1007 is a cell-permeable, potent, reversible and substrate competitive LSD1 selective inhibitor with IC50 of 5.27 uM. |
| PC-23999 |
CBB1003
LSD1 inhibitor
|
CBB1003 is a novel lysine-specific demethylase 1 (LSD1) inhibitor with IC50 of 10.54 uM. |
| PC-23897 |
FTO inhibitor Dac85
FTO inhibitor
|
FTO inhibitor Dac85 is a small molecule inhibitor of fat mass and obesity-associated protein (FTO) with IC50 of 0.7 uM, displays strong antiproliferative effect on AML cells. |
| PC-23879 |
N-CDPCB
FTO inhibitor
|
N-CDPCB is a small molecule inhibitor of fat mass and obesity associated protein (FTO), displays strong inhibitory activity of demethylation of the ssRNA by FTO with IC50 of 4.95 uM. |
| PC-23878 |
FTO inhibitor 8t
FTO inhibitor
|
FTO inhibitor 8t is a novel specific small molecule inhibitor of RNA demethylase FTO with IC50 of 7.3 uM. |
