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Cat. No. Product Name Information
PC-23356

S2157

LSD1 inhibitor

S2157 is a selective, brain-permeable inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with IC50 of 0.89 uM, >200-fold selective over LSD2, MAO-A and MAO-B.
PC-23355

S2172

LSD1 inhibitor

S2172 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with Ki of 0.27 uM.
PC-23354

S2116

LSD1 inhibitor

S2116 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) withIC50 of 0.74 uM.
PC-23285

NCL-1

LSD1 inhibitor

NCL-1 is a specific small molecule inhibitor of LSD1 (KDM1A) with IC50 of 2.5 uM.
PC-23163

P3FI-63

KDM3B inhibitor

P3FI-63 is a small molecule PAX3-FOXO1 activity inhibitor, blocks PAX3-FOXO1 downstream target gene expression, inhibits multiple KDMs including KDM3B, KDM4B, KDM5A, and KDM6B, with highest potency against KDM3B (IC50=7 uM).
PC-22985

YTH domain inhibitor N-7

m6A YTH domain inhibitor

YTH domain inhibitor N-7 is a specific small molecule, pan-inhibitor of YTH domain-containing m6A RNA readers with IC50 of 30-48 uM for human YTHDF1, YTHDF2, YTHDF3, YTHDC1, and YTHDC2 proteins.
PC-22960

ML234

EZH2/LSD1 inhibitor

ML234 is a potent EZH2/LSD1 dual inhibitor with IC50 of 0.09/0.12 uM respectively, shows excellent antiproliferative capacity against prostate cancer cell lines LNCAP, PC3, and 22RV1.
PC-22951

GSK-J5

GSK-J5 is the ethyl ester pro-drug of GSK-J2, which lacks H3K27 demethylase activity as a inactive control molecule for GSK-J4.
PC-22847

FTO inhibitor FB23

FTO inhibitor

FTO inhibitor FB23 is a potent and selective FTO demethylase inhibitor with IC50 of 60 nM, directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.
PC-22677

DDO-2728

ALKBH5 inhibitor

DDO-2728 is a selectiv, 2-OG independent inhibitor of mRNA m6A demethylase AlkB homologue 5 (ALKBH5) with IC50 of 2.97 uM in FP assays, does not inhibit FTO (ALKBH9) and ALKBH3.
PC-22581

TACH101 L-lysine

KDM4 inhibitor

TACH101 (Zavondemstat, QC8222, TACH 101) L-lysine is a reversible, α-ketoglutarate competitive, selective and potent inhibitor of KDM4 isoforms A-D with IC50 values of 80 nM against all four isoforms.
PC-22360

KDM4/5 inhibitor 19a

KDM4/5 inhibitor

KDM4/5 inhibitor 19a is a potent, cell penetrant, dual KDM4/5-subfamily inhibitor with Ki values of 4 nM/7 nM for KDM4A/KDM5B, respectively.

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