| Cat. No. |
Product Name |
Information |
| PC-23648 |
ZLD115
FTO inhibitor
|
ZLD115 is a potent, selective inhibitor of fat mass and obesity-associated protein (FTO) with IC50 of 2.3 uM in PAGE-based assays. |
| PC-23548 |
Rhein
ALKBH inhibitor
|
Rhein is a pan inhibitor of the ALKBH proteins, inhibits ALKBH2, ALKBH3 and FTO with IC50 values of 9.1 μM, 5.3 μM and 21.0 μM, respectively. |
| PC-23547 |
ALKBH2 inhibitor AH2-14c
ALKBH2 inhibitor
|
ALKBH2 inhibitor AH2-14c is the ethyl ester, cell membrane permeable prodrug of AH2-15c, which is a potent and selective inhibitor of 2OG-dependent DNA demethylase AlkB homolog 2 (ALKBH2) with IC50 of 31 nM. |
| PC-23546 |
ALKBH2 inhibitor AH2-15c
ALKBH2 inhibitor
|
ALKBH2 inhibitor AH2-15c is a potent and selective inhibitor of 2OG-dependent DNA demethylase AlkB homolog 2 (ALKBH2) with IC50 of 31 nM in fluorescence polarization (FP) assays, >200-fold selectivity over other AlkB subfamily members. |
| PC-23356 |
S2157
LSD1 inhibitor
|
S2157 is a selective, brain-permeable inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with IC50 of 0.89 uM, >200-fold selective over LSD2, MAO-A and MAO-B. |
| PC-23355 |
S2172
LSD1 inhibitor
|
S2172 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with Ki of 0.27 uM. |
| PC-23354 |
S2116
LSD1 inhibitor
|
S2116 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) withIC50 of 0.74 uM. |
| PC-23285 |
NCL-1
LSD1 inhibitor
|
NCL-1 is a specific small molecule inhibitor of LSD1 (KDM1A) with IC50 of 2.5 uM. |
| PC-23163 |
P3FI-63
KDM3B inhibitor
|
P3FI-63 is a small molecule PAX3-FOXO1 activity inhibitor, blocks PAX3-FOXO1 downstream target gene expression, inhibits multiple KDMs including KDM3B, KDM4B, KDM5A, and KDM6B, with highest potency against KDM3B (IC50=7 uM). |
| PC-22985 |
YTH domain inhibitor N-7
m6A YTH domain inhibitor
|
YTH domain inhibitor N-7 is a specific small molecule, pan-inhibitor of YTH domain-containing m6A RNA readers with IC50 of 30-48 uM for human YTHDF1, YTHDF2, YTHDF3, YTHDC1, and YTHDC2 proteins. |
| PC-22960 |
ML234
EZH2/LSD1 inhibitor
|
ML234 is a potent EZH2/LSD1 dual inhibitor with IC50 of 0.09/0.12 uM respectively, shows excellent antiproliferative capacity against prostate cancer cell lines LNCAP, PC3, and 22RV1. |
| PC-22951 |
GSK-J5
|
GSK-J5 is the ethyl ester pro-drug of GSK-J2, which lacks H3K27 demethylase activity as a inactive control molecule for GSK-J4. |
