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Chemical Structure : T-3775440
CAS No.: 1422620-34-5
Catalog No.: PC-60264Not For Human Use, Lab Use Only.
T-3775440 (T 3775440, T3775440) is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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T-3775440 (T 3775440, T3775440) is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
T-3775440 displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B).
T-3775440 disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models.
| M.Wt | 310.401 | |
| Formula | C18H22N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-((1S,2R)-2-((cyclopropylmethyl)amino)cyclopropyl)phenyl)-1-methyl-1H-pyrazole-4-carboxamide |
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1. Takagi S, et al. Cancer Res. 2017 Jun 30. pii: canres.3502.2016.
2. Ishikawa Y, et al. Mol Cancer Ther. 2017 Feb;16(2):273-284.
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