ALKBH5 inhibitor 18l

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Chemical Structure : ALKBH5 inhibitor 18l

Catalog No.: PC-24023Not For Human Use, Lab Use Only.

ALKBH5 inhibitor 18l is a potent, selective, covalent inhibitor of N6-methyladenosine (m6A) demethylase ALKBH5 with Kd of 804 nM, IC50 of 0.62 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ALKBH5 inhibitor 18l is a potent, selective, covalent inhibitor of N6-methyladenosine (m6A) demethylase ALKBH5 with Kd of 804 nM, IC50 of 0.62 uM.
ALKBH5 inhibitor 18l is a highly selective inhibitor of ALKBH5 rather than FTO.
ALKBH5 inhibitor 18l exerts potent antiproliferative effect on NB4 cells with IC50 of 0.63 μM.
ALKBH5 inhibitor 18l directly targeted ALKBH5 in cells and altered m6A levels on mRNA, blocked the related downstream signal pathways, promoted differentiation, and induced apoptosis.

Physicochemical Properties

M.Wt	231.25
Formula	C13H13NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-methoxyphenethyl)-1H-pyrrole-2,5-dione

References

1. Wu H, et al. Angew Chem Int Ed Engl. 2025 Feb 20:e202424928.

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