KDM5A-IN-1 |CAS:1905481-36-8 Probechem Biochemicals

Chemical Structure : KDM5A-IN-1

CAS No.: 1905481-36-8

KDM5A-IN-1

Catalog No.: PC-42028Not For Human Use, Lab Use Only.

KDM5A-IN-1 is a potent, orally bioavailable histone lysine demethylases 5 (KDM5) inhibitor with IC50 of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively.

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Biological Activity

KDM5A-IN-1 is a potent, orally bioavailable histone lysine demethylases 5 (KDM5) inhibitor with IC50 of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively.

KDM5A-IN-1 shows EC50 value of 960 nM for PC9 H3K4Me3, and less potent against other KDM enzymes (1A, 2B, 3B, 4C, 6A, 7B).

Physicochemical Properties

M.Wt	290.3608
Formula	C15H22N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclopropanecarboxamide, N-[(3R)-1-[[5-(1-methylethyl)-1H-pyrazol-3-yl]carbonyl]-3-pyrrolidinyl]-

References

1. Kwong Wah LAI, et al. WO 2016057924 A1 20160414.

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KDM5A-IN-1

Biological Activity

Physicochemical Properties

References

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