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D-alpha-Hydroxyglutaric acid disodium

Chemical Structure : D-alpha-Hydroxyglutaric acid disodium

CAS No.: 103404-90-6

D-alpha-Hydroxyglutaric acid disodium (D-2-HG;D-2-hydroxyglutarate)

Catalog No.: PC-42195Not For Human Use, Lab Use Only.

D-alpha-Hydroxyglutaric acid disodium (D-2-HG, D-2-hydroxyglutarate) is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.

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Biological Activity

D-alpha-Hydroxyglutaric acid disodium (D-2-HG, D-2-hydroxyglutarate) is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
D-2-HG partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively.
D-2-HG comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM.
D-2-HG binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells

Physicochemical Properties

M.Wt 192.08
Formula C5H6Na2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 32 mg/mL

Chemical Name/SMILES

Pentanedioic acid, 2-hydroxy-, disodium salt, (2R)-

References

1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.

2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.

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