Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : P3FI-63
CAS No.: 931596-95-1
Catalog No.: PC-23163Not For Human Use, Lab Use Only.
P3FI-63 is a small molecule PAX3-FOXO1 activity inhibitor, blocks PAX3-FOXO1 downstream target gene expression, inhibits multiple KDMs including KDM3B, KDM4B, KDM5A, and KDM6B, with highest potency against KDM3B (IC50=7 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $138 | In stock | |
| 100 mg | Get quote | ||
| 250 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
P3FI-63 is a small molecule PAX3-FOXO1 activity inhibitor, blocks PAX3-FOXO1 downstream target gene expression, inhibits multiple KDMs including KDM3B, KDM4B, KDM5A, and KDM6B, with highest potency against KDM3B (IC50=7 uM).
P3FI-63 treatment closely phenocopied shRNA knockdown of PAX3-FOXO1.
P3FI-63 shows EC50 of 1.7-7.5 uM on FP-RMS cell lines RH4, RH30, and SCMC cancer cells.
P3FI-63 shows no inhibitory activity against HDAC1, HDAC2, HDAC3, or PRMT5.
| M.Wt | 269.30 | |
| Formula | C15H15N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Pyridinecarboxylic acid, 2-(3,5-dimethylbenzoyl)hydrazide |
|
1. Kim YY, et al. Nat Commun. 2024 Feb 24;15(1):1703.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
