Chemical Structure : CBB1007 trihydrochloride
Catalog No.: PC-24001Not For Human Use, Lab Use Only.
CBB1007 trihydrochloride is a cell-permeable, potent, reversible and substrate competitive (LSD1, KDM1A) selective inhibitor with IC50 of 5.27 uM.
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CBB1007 trihydrochloride is a cell-permeable, potent, reversible and substrate competitive (LSD1, KDM1A) selective inhibitor with IC50 of 5.27 uM.
CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities.
CBB1007 induces activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM).
CBB1007 preferentially arrests the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cell.
M.Wt | 644.00 | |
Formula | C27H37Cl3N8O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Jing Wang, et al. Cancer Res. 2011 Dec 1;71(23):7238-49.
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