Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : KDOAM-25 citrate
CAS No.: 2448475-08-7
Catalog No.: PC-21988Not For Human Use, Lab Use Only.
KDOAM-25 citrate (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family (JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
KDOAM-25 citrate (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family (JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively.
KDOAM-25 weakly inhibits KDM4C/KDM2B (IC50=4.8/4.4 uM) and good selectivity over other demethylases.
KDOAM-25 most potently inhibits KDM5B (IC50=50 uM) and increases H3K4me3 levels in Hela cells.
KDOAM-25 increases global H3K4 methylation, causes G1 cell-cycle arrest and impairs cell proliferation in multiple myeloma MM1S cells.
| M.Wt | 499.52 | |
| Formula | C21H33N5O9 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinamide 2-hydroxypropane-1,2,3-tricarboxylate |
|
1. Tumber A, et al. Cell Chem Biol. 2017 Mar 16;24(3):371-380.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
