KDM5-C49 hydrochloride

Chemical Structure : KDM5-C49 hydrochloride

CAS No.: 3026728-26-4

Catalog No.: PC-26560Not For Human Use, Lab Use Only.

KDM5-C49 hydrochloride is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively.

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5 mg	$128	In stock
10 mg	$198	In stock
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Biological Activity

KDM5-C49 hydrochloride is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively.
KDM5-C49 displays 25-100-fold selectivity over KDM6B, 2-30-fold selectivity over KDM4 family, but with less cell-permeablity.

Physicochemical Properties

M.Wt	344.84
Formula	C15H25ClN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid hydrochloride

References

1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45.

2. Horton JR, et al. Cell Chem Biol. 2016 Jul 21;23(7):769-81.

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