NCGC00247743

Chemical Structure : NCGC00247743

CAS No.: 1435192-04-3

Catalog No.: PC-26949Not For Human Use, Lab Use Only.

NCGC00247743 is a selective inhibitor of histone lysine demethylase KDM4/JMJD2s with IC50 of 10 nM for KDM4B, inhibits LNCaP cell growth with IC50 in the μM range, shows no or weak activity for KDM5A/JARID1A.

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Biological Activity

Physicochemical Properties

M.Wt	391.52
Formula	C24H29N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(dimethylamino)hexyl)-3-(8-hydroxyquinolin-6-yl)benzamide

References

1. Duan L, et al. KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. Chem Biol. 2015 Sep 17;22(9):1185-96.

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NCGC00247743

Biological Activity

Physicochemical Properties

References

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