Chemical Structure : Pulrodemstat benzenesulfonat
CAS No.: 2097523-60-7
Catalog No.: PC-38672Not For Human Use, Lab Use Only.
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM.
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10 mg | $138 | In stock | |
25 mg | $228 | In stock | |
50 mg | $378 | In stock | |
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Pulrodemstat (CC90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM.
CC-90011 inhibits gastrin-releasing peptide (GRP) mRNA expression in H209 and H1417 cell lines with IC50 of 3 nM and 4 nM, respectively.
CC-90011 exhibits potent antiproliferative activity (EC50=6 nM, H1417) that correlated with GRP suppression.
CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.
M.Wt | 609.649 | |
Formula | C30H29F2N5O5S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
4-[2-(4-Amino-piperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile benzenesulfonic acid |
1. Kanouni T, et al. J Med Chem. 2020 Dec 10;63(23):14522-14529.
2. Hollebecque A, et al. Clin Cancer Res. 2021 Jan 15;27(2):438-446.
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