Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MO-I-500
CAS No.: 1585219-04-0
Catalog No.: PC-72386Not For Human Use, Lab Use Only.
MO-I-500 is a pharmacological inhibitor of FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $488 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MO-I-500 is a pharmacological inhibitor of m6A demethylase FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM.
MO-I-500 treated cells exhibited a global increase in RNA methylation.
HeLa cells treated with 25 μM MO-I-500 for 24 hours showed a 9.3% increase in N6-methyl-adenosine content in total RNA.
MO-I-500 treatment caused a dramatic (>95%) inhibition in colony formation in SUM149-Luc cells.
MO-I-500 modulates various microRNA in treated (25uM) HeLa cells.
MO-I-500 treatment also led to decreased levels of FTO and IRX3 proteins in the SUM149 cells, with relatively little effect on cell growth.
MO-I-500 can strongly reduce the adverse effects of streptozotocin (STZ) model of AD in human astrocytoma CCF-STTG1 cells.
| M.Wt | 317.74 | |
| Formula | C12H12ClNO5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Ethanesulfonamide, N-[5-(4-chlorophenyl)-3,4-dihydroxy-2-furanyl]- |
|
1. Guanqun Zheng, et al. ACS Chem Neurosci. 2014 Aug 20;5(8):658-65.
2. Singh B, et al. PLoS One. 2016 Jul 8;11(7):e0159072.
3. Cockova Z, et al. ACS Chem Neurosci. 2021 Oct 20;12(20):3818-3828.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
