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Chemical Structure : MO-I-500
Catalog No.: PC-72386Not For Human Use, Lab Use Only.
MO-I-500 is a pharmacological inhibitor of FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM.
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MO-I-500 is a pharmacological inhibitor of m6A demethylase FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM.
MO-I-500 treated cells exhibited a global increase in RNA methylation.
HeLa cells treated with 25 μM MO-I-500 for 24 hours showed a 9.3% increase in N6-methyl-adenosine content in total RNA.
MO-I-500 treatment caused a dramatic (>95%) inhibition in colony formation in SUM149-Luc cells.
MO-I-500 modulates various microRNA in treated (25uM) HeLa cells.
MO-I-500 treatment also led to decreased levels of FTO and IRX3 proteins in the SUM149 cells, with relatively little effect on cell growth.
MO-I-500 can strongly reduce the adverse effects of streptozotocin (STZ) model of AD in human astrocytoma CCF-STTG1 cells.
| M.Wt | 317.74 | |
| Formula | C12H12ClNO5S | |
| Appearance | Solid | |
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1. Guanqun Zheng, et al. ACS Chem Neurosci. 2014 Aug 20;5(8):658-65.
2. Singh B, et al. PLoS One. 2016 Jul 8;11(7):e0159072.
3. Cockova Z, et al. ACS Chem Neurosci. 2021 Oct 20;12(20):3818-3828.
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