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Chemical Structure : Bomedemstat
CAS No.: 1990504-34-1
Catalog No.: PC-20255Not For Human Use, Lab Use Only.
Bomedemstat (IMG-7289) is a potent, selective, irreversible and orally active LSD1 (KDM1A) inhibitor, increases H3K4 and H3K9 methylation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $468 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Bomedemstat (IMG-7289) is a potent, selective, irreversible and orally active LSD1 (KDM1A) inhibitor, increases H3K4 and H3K9 methylation.
Bomedemstat (IMG-7289) potentiated responses to PD-1 inhibition in a syngeneic model of SCLC, resulting in increased CD8+ T-cell infiltration and strong tumor growth inhibition.
Bomedemstat (IMG-7289) increased MHC class I expression in mouse SCLC tumor cells in vivo and augmented MHC-I induction by IFNγ and increased killing by tumor-specific T cells in cell culture.
Bomedemstat (IMG-7289) inhibits the production of inflammatory cytokines, impairs self-renewal and proliferation of neoplastic stem cells, and shows significant disease-modifying activities in multiple non-clinical models of myelofibrosis.
| M.Wt | 519.63 | |
| Formula | C28H34FN7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1S)-4-[[(1R,2S)-2-(4-Fluorophenyl)cyclopropyl]amino]-1-[(4-methyl-1-piperazinyl)carbonyl]butyl]-4-(1H-1,2,3-triazol-1-yl)benzamide |
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1. Jutzi JS, et al. Hemasphere. 2018 Jun 8;2(3):e54.
2. Hiatt JB, et al. Clin Cancer Res. 2022 Oct 14;28(20):4551-4564.
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